The use of new technologies in oncology has greatly increased the rate of survival of patients with malignant neoplasms. Another thing is young female patients suffering from cancers, who have to choose between treatment and motherhood, since chemo-radiation therapy leads to a premature menopause in women of childbearing age.
One of the main methods to preserve fertility in young women with cancer pathology is the cryonic conservation of genetic material: embryos, oocytes and ovarian tissues. That is why the method of cryonic conservation of ovarian tissue becomes increasingly more frequent in complex treatment of malignant neoplasms in women.
It has been common to freeze the ovary tissue through slow programmable freezing with subsequent autotransplantation following the treatment of the woman. This is common practice abroad. The first transplant operation to ensure pregnancy was carried out in Brussels in 2004-2005, followed by a similar operation in Tel Aviv. There are two ways to freeze tissue. Actually all world nations have opted for the so-called slow freezing, boasting more than 40 childbirths to date. Everyone has rejected “flash” freezing, or vitrification.
“We have been the first in Russia and the world, says Marina Kiseleva, Head of the Department of New Medical Technologies of A. Tsyb Medical Radiological Research Center, branch of the FSBI NMRRC of the Ministry of Health of the Russian Federation. The tissue proved viable and a patient at the Centre became pregnant. One should have seen the happy face of a woman looking at her newly born baby to understand what the young mother felt now that she used the only chance that the Centre doctors had granted her.
Marina Victorovna Kiseleva, author of unique technology to preserve genetic material through “flash” freezing, professor, Head of Department of New Medical Technologies of A.Tsyb Medical Radiological Research Center, branch of the FSBI NMRRC of the Ministry of Health of the Russian Federation, with her colleagues and the first baby boy, delivered by his mother who had undergone the full course of treatment for thyroid cancer.
The first cryobank of cancer patients’ genetic material has been operational at A. Tsyb Medical Radiological Research Center since 2006. The Centre cryobank has accumulated 1400 samples of genetic material to date.