UNIQUE TECHNOLOGY OF PRESERVATION OF GENETIC MATERIAL USING FLASH FREEZE METHOD
Use of new technologies in oncology provided for great improvement of survival of patients with malignant neoplasms. Another issue is presented by the young patients suffering from cancers, who have to choose between treatment and motherhood, since in the women of childbearing age chemoradiation therapy leads to premature menopause.
One of the main methods to preserve fertility in young women with cancer pathology is the cryonic conservation of genetic material: embryos, oocytes and ovarian tissues. That is why the method of cryonic conservation of ovarian tissue becomes more and more frequent in complex treatment of malignant neoplasms in women.
A common method of ovarian tissue freezing was the method of programmed slow freezing followed by autologous transplant after completion of the treatment of women. Such operations are carried out abroad. The first transplant for pregnancy was made in 2004-2005 in Brussels, the second in Tel Aviv. In the world there are two ways of freezing tissue. The whole world followed the path of the so-called “slow freezing”, today this method resulted in more than 40 children born in the world, but nobody went on the “fast” way of vitrification.
"We were the first in the world and in Russia", said Marina Kiselyova - head of the department of new medical technologies of MRRC n.a. A.F. Tsyba - branch of FSBI NMRRC of the Ministry of Health of Russia. It turned out that the tissue is viable and the Center was able to achieve the pregnancy of a woman. You should see the happy face of a woman, prone to the kid to understand the feeling experienced by a young mother, which the doctors of the Center presented the only chance in her life.
Marina Viktorovna Kiselyova,
the author of the unique technology of the conservation of genetic material by the rapid freezing,
professor, head of the department of new medical technologies
of MRRC n.a. A.F. Tsyba - branch of FSBI NMRRC of the Ministry of Health of Russia
with colleagues, and the first boy born to a patient who underwent
full course of treatment of a malignant tumor of the thyroid.
Since 2006 MRRC n.a. A.F. Tsyba - branch of FSBI NMRRC of the Ministry of Health of Russia operates first Cryobank of genetic material of cancer patients. To date, the Center Cryobank has 1,400 samples of genetic material.
Clinical case: Patient E., born in 1986, was admitted to MRRC n.a. A.F. Tsyba - branch of FSBI NMRRC of the Ministry of Health of Russia with a diagnosis of “Papillary thyroid cancer stage IV with metastatic lymph nodes of the neck”. Due to the fact that the patient was planned to undergo a course of postoperative radioiodine therapy in 2010 there were simultaneously performed surgery to remove the thyroid and lymph nodes of the neck and taking endoscopic ovarian tissue for fast freezing - vitrification. In the second phase the patient underwent conservative radioiodine therapy. Over the next 2 years during treatment the patient entered menopause, indicating the loss of the possibility of pregnancy;
In after 2 years of remission of the disease in 2012, it was decided to perform the transplantation of ovarian tissue. And good luck! There was normalization of the menstrual cycle, which allowed us to obtain embryos. After implantation, in December 2014 the patient had long-awaited pregnancy, which ended in the birth of a son! Rightfully the clinic, and the Center, and Russia can be proud of the achievements of scientists!
Reporting for the TV channel Moscow-24 (28.08.2015)