Federal State Budgetary Institution
National Medical Research Radiological Center
of the Ministry of Health of the Russian Federation

Topics of the state order given to FSBI NMRRC of the Ministry of Health of the Russian Federation for 2015-2018

No Topic of the state order Work content
1 Development of molecular-genetic technologies for monitoring of solid malignant tumors with the use of circulating nucleic acids (“liquid biopsy”) for optimizing the antitumor therapy Collection of samples and development of the representative collection of samples of reliably diagnosed patients. Testing the methodological part of analysis performance. Development of the mathematical support for analysis of results.
2 Studies of biological peculiarities of multipotent mesenchymal stromal cells (MMSC) of adipose tissue (AT) of patients with malignant tumors of reproductive organs (MTRO). Studies of peculiarities of the bone metabolism at various oncourological disorders.

Development of MMSC protocols extraction from AT of patients with mammary gland cancer of the stages 1-11, obtaining the primary culture of MMSC and its management within passages. Creation of the collection of samples of AT MMSC cultures of patients first diagnosed with mammary gland cancer of the stages 1-11 and healthy donors in the cryobank of the prognosis laboratory. Estimation of the proliferative potential, efficiency of colony formation, study of morphological and immune phenotype (expression of the series of surface antigens) of the collection of samples of AT MMSC of first-diagnosed patients with mammary gland cancer and healthy donors.

Studies of plasticity (the ability to induced differentiation under conditions in vitro in the osseo and adipogenic areas) of samples of AT MMSC cultures of patients with mammary gland cancer and healthy donors, coupled with analysis of their individual peculiarities and comparative morpho-functional assessment. Certification of samples of AT MMSC cultures of patients with mammary gland cancer.

Studies of biosafety of the autologous MMSC culture usage in model experiments in vivo

3

Development of the new efficient screening methods of malignant new growths of reproductive organs. Organ-preserving treatment of invasive cervical cancer of stages 1a2 – 1b1.

Conservative treatment of uterine corpus carcinoma of young patients. Studies of the morpho-functional condition of the vitrified condition of the ovary of oncology patients in systems in vitro and in vivo and estimation of the ovarian reserve with the purpose of preserving the reproductive function. Diagnosis, treatment and prevention of reproductive malfunction in men.

Designing a no-dose beam screening device in order to select women in the risk group of mammary gland disorders

Work-through the methodological aspects of its operation.

Clinical tests of the device, the set of clinical material with options of the age norm and different types of alterations of the mammary gland.

Comparative analysis of the obtained results and the mammographic and ultrasound data and pathomorphological studies.

Development of the image semiotics of the age norm diversity and various mammary gland disorders.

Statistical processing, analysis of the study results.

Preparation of the photo collection for educational guidelines

4 Diagnosis, treatment and rehabilitation of children with congenital and acquired urogenital disorders. Development and improvement of the treatment methods of different birth defects of the urogenital system of children, including hypospadias, epispadias, and extrophy of bladder. Studies of possibilities of treatment of urological disorders among children by means of low-invasive endoscopic methods.
5 Development of low-invasive diagnosis, treatment and rehabilitation methods of malfunctions of the lower urinal tract (LUT) of children and adults. Studies of pathogenesis and peculiarities of the congenital immune response of the bladder’s mucous membrane of patients with the recurring infection of LUT. Development of the complex low-invasive diagnosis algorithm of patients of different age with acraturesis. Identification of the optimal set of clinical, urodynamic and neurophysiological studies in case of different disorders accompanied with acraturesis. Development of the medical-technical specification for the design of the Russian non-invasive device for urological studies with the on-line sensor and its approbation in the clinical setting.
6 Preclinical and clinical studies of selective management possibilities of radiation sensitivity of tumors and protection from damage of normal tissues.
  1. Studies of management possibilities of radiation sensitivity of tumors.
  2. Development and improvement of patients’ treatment methods using electro-magnetic hypyrexia.
  3. Improvement of technologies of photodynamic therapy of tumors.
  4. Preclinical studies of radiation sensitizing activity of the detonation nano-diamonds and salinomycine complex.
7 Development of new high-tech methods and approaches to diagnosis and therapy of malignant new growths in the experimental setting

Development of the study approaches of gene-therapeutic aids of different nature in systems in vitro and in vivo and estimation of efficiency of their antitumor action.

Development of the study approaches of gene-therapeutic aids of different nature in systems in vitro and in vivo and estimation of efficiency of their antitumor action and safety.

Development of modification methods of the conventional antitumor therapies effect using gene-engineering products of different nature and mechanism of action.

8 Optimization of the cytological and histological diagnosis of pre-tumors and tumors with different localization by means of using contemporary high-tech methods of investigation.
  1. Development of optimal immune-morphological panels for diagnosis and determination of prognostic and predictive factors in case of tumors of different localizations.
  2. Aprobation of basic molecular-genetic markers having significance for diagnosis of the prognosis and identification of the treatment tactics of tumors of different localizations.
  3. Proposal of complex schemata of liquid cytology combined with immunocytochemistry and molecular-genetic methods for early diagnosis of precarcinogenic conditions and cervical cancer, cancer of perianal area, throat and oropharynx.
  4. Development and introduction of fluorescent techniques (visualization of photo sensitizers, fluorescent immunocytochemistry) for intraoperative morphological diagnosis of the carcinogenic process distribution degree
9 Study of pathogenesis of kidney stone disease (KSD). Studies of the role of the metabolic type of KSD, crystal formation physical and chemical peculiarities, genetic risk factors and the metabolic syndrome in KSD pathogenesis for improvement of medical aid to the patients with nephrolithiasis. Development of the complex of measures, intended for diagnosis, treatment and prophylactics of development of KSD with the account for risk factors and new data about the disease’s pathogenesis.
10 Development of new nuclear medicine technologies and optimization of the beam therapy of oncology diseases.
  1. Justification and approbation of the beam therapy of malignant new growths with the use of dense-ionizing radiation.
  2. Justification and approbation of innovative radiopharmaceutical preparations on the basis of albumin micro-spheres and Rhenium-188 for the purposes of the radionuclide therapy of malignant growths in liver and rheumatoid arthritis.
  3. Justification and approbation of the innovative complex of methods of in vivo dosimetry in oncoradiology.
  4. Justification and approbation of methods of planning radionuclide therapy of oncology patients with metastases in the skeleton.
11 Study of radiation risks of oncology morbidity and mortality in humans at the action of ionizing radiation.
  1. Study and estimate of coefficients of models of radiation risks of ICPR, UNSCEAR and WHO on the basis of direct radiation-epidemiological studies with participation of Russian cohorts of radiation-exposed people.
  2. Radiation-epidemiological study of dose-effect dependencies for oncology morbidity and mortality of humans in the zone of low doses.
  3. Study of the effect of heterogeneity of the radiation-exposed populations on estimates of radiation-related risks of oncology mortality and morbidity.
12 Development and optimizing of high-tech techniques of head and neck tumors beam therapy, tumors of the central nervous system, organs of thoracic cavity, the gastrointestinal tract, prostate, female reproductive organs, mammary gland, and locomotor system with the use of capabilities of the modern radiotherapeutic technology and radio modification.

Development of high-dose beam therapy methods in case of primary and metastatic tumors of different localizations with the use of the modern radiotherapeutic technology.

Preparation of new programs of beam therapy with the use of different radio modifiers.

Clinical use of the developed treatment techniques with estimate of the direct antitumor effect.

Clinical use of the developed techniques

13 Development of new approaches to treatment of patients with locally distributed and disseminated forms of malignant tumors of the gastrointestinal tract (GIT; stomach, spleen, ad colorectal carcinomas) with the use of different variants of intra-peritoneal therapy. Development of original treatment methods of patients with disseminated stomach cancer and colon cancer, using two variants of intra-peritoneal chemotherapy, as well as the method of combined spleen cancer treatment with the use of hyperthermal intraoperative intraperitoneal chemotherapy. Estimation of direct and short-run outcomes of the treatment, evidencing tolerability and efficiency of the proposed methods of treatment Development of the algorithm of selection of the method of treatment of locally distributed and disseminated forms of malignant tumors of GIT.
14 Development and introduction of organizational and information technologies on the basis of the State Cancer Registry, intended for boosting the efficiency of the oncology service and prophylactics of malignant new growths in the Russian Federation.

Improvement of information-analytical systems of the cancer registry at regional and federal levels.

Performance of the comparative assessment of basic indicators of the oncology service in the Russian regions, federal districts (morbidity, mortality, prevalence of malignant new formations with the account of gender and age characteristics).

Analysis and monitoring of efficiency of preventive measures taken for certain groups of the population of the Russian Federation.

Development of regional programs of prevention and screening of malignant tumors on the basis of the unified database of the state cancer registry.

Development of the methodology of prognostic oncology indicators function of different natural, technogenic and social factors.

Development of tenets of complex analysis of indicators of oncology aid to the population of the Russian Federation on the basis of the state registry data

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